- BS, University of Arizona, Molecular and Cellular Biology / Finance, 2005
- PhD, University of Arizona, Neuroscience, 2013
- MD, University of Arizona, 2013
Nicotine, a known neuroteratogen, can cause central respiratory disorders, including Sudden Infant Death Syndrome (SIDS), in infants born to mothers that smoked during pregnancy. It is thought that nicotine causes developmental alterations in neurons located in respiratory control centers of the medulla. My project focuses on studying the cellular effects of nicotine on neurons in the preBotzinger complex and the hypoglossal motor nucleus; both are regions critical to respiratory control. Specifically, I am interested in the consequences of prenatal nicotine exposure on fast inhibitory and excitatory neurotransmission involving GABA-A and AMPA receptors, respectively, in these 2 regions of the brainstem. The studies involve using Western blotting and immunohistochemistry to examine receptor expression and electrophysiology to assess neurotransmission in the areas of interest.
BioME Graduate Fellowship Award, NSF, 2009
Outstanding Neuroscience Graduate Student Award (category: teaching), 2009
Developmental nicotine exposure alters AMPA neurotransmission in the hypoglossal motor nucleus and pre-Botzinger complex of neonatal rats.
J Neurosci. 2013 Feb 6:33(6):2616-25. doi: 10.1523/JNEUROSCI.3711-12.2013
- Jaiswal SJ, Pilarski JQ, Harrison CM, Fregosi RF.
Influence of prenatal nicotine exposure on development of the ventilatory response to hypoxia and hypercapnia in neonatal rats.
J Appl Physiol. 2010 Jul:109(1):149-58. Epub 2010 Apr 29.
- Huang YH, Brown AR, Cross SJ, Cruz J, Rice A, Jaiswal S, Fregosi RF.
Presentations and Abstracts (outside the University of Arizona):
- Stuti J Jaiswal, Jason Pilarksi and Ralph F Fregosi.
Developmental nicotine exposure alters GABAergic and AMPAergic neurotransmission in the hypoglossal motor nucleus.
Society for Neuroscience, Nov 2011.
- Stuti J Jaiswal and Ralph F Fregosi.
GABA-A receptor expression in the preBotzinger complex region of develping rats prenatally exposed to nicotine.
Society for Neuroscience, Nov 2010.